GrantRound

Open Federal Grants · National Institutes of Health

Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)

National Institutes of Health · Opportunity PAR-25-442 · Award amount: see the official listing

Opportunity NumberPAR-25-442
Award FloorNot stated in the listing
Award CeilingNot stated in the listing
Cost Sharing / MatchingNot required by the listing
Application DeadlineFeb 17, 2028
Last Updated on Grants.govJul 29, 2025
Who Can ApplyState governments, County governments, City / township governments, Regional organizations, U.S. territories & freely associated states, Independent school districts, Federally recognized tribal governments, Public housing authorities, Native American tribal organizations, Nonprofits with 501(c)(3) status, Nonprofits without 501(c)(3) status, Private colleges / universities, For-profit organizations, Small businesses, Other applicants

Eligibility

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-b

Eligibility text quoted from the official Grants.gov listing.

About This Opportunity

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for exploratory and early-stage projects that focus on undruggable target classes within intractable human disease. Applicants will identify a human disease relevant undruggable target class and develop a method or agent that is selective for one or more targets within that target class. This NOFO is intended to jumpstart research that demonstrates innovative strategies to modulate targets that cannot be addresse …

Description from the official Grants.gov listing — read the complete notice, including any updates, on Grants.gov before applying.

Check Your Fit Get Deadline Reminders

View the official listing on Grants.gov →

More Open Grants From NIH

Browse Open Grants

By who can apply:

By agency:

By closing month:

Every grant listed here comes from Grants.gov, the official U.S. government database. Award amounts and deadlines can change — verify the details on the official listing before you apply. GrantRound is not affiliated with the U.S. government.