GrantRound

Open Federal Grants · National Institutes of Health

Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)

National Institutes of Health · Opportunity PAR-25-446 · Awards up to $3,000,000

Opportunity NumberPAR-25-446
Award FloorNot stated in the listing
Award Ceiling$3,000,000
Cost Sharing / MatchingNot required by the listing
Application DeadlineAug 21, 2028
Last Updated on Grants.govSep 10, 2025
Who Can ApplyState governments, County governments, City / township governments, Regional organizations, U.S. territories & freely associated states, Independent school districts, Federally recognized tribal governments, Public housing authorities, Native American tribal organizations, Nonprofits with 501(c)(3) status, Nonprofits without 501(c)(3) status, Private colleges / universities, For-profit organizations, Small businesses, Other applicants

Eligibility

Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.)

Eligibility text quoted from the official Grants.gov listing.

About This Opportunity

The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption. This …

Description from the official Grants.gov listing — read the complete notice, including any updates, on Grants.gov before applying.

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