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Open Federal Grants · National Institutes of Health

Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R21 Clinical Trial Not Allowed)

National Institutes of Health · Opportunity PAR-25-450 · Award amount: see the official listing

Opportunity NumberPAR-25-450
Award FloorNot stated in the listing
Award CeilingNot stated in the listing
Cost Sharing / MatchingNot required by the listing
Application DeadlineJul 20, 2028
Last Updated on Grants.govSep 23, 2025
Who Can ApplyState governments, County governments, City / township governments, Regional organizations, U.S. territories & freely associated states, Independent school districts, Federally recognized tribal governments, Public housing authorities, Native American tribal organizations, Nonprofits with 501(c)(3) status, Nonprofits without 501(c)(3) status, Private colleges / universities, For-profit organizations, Small businesses, Other applicants

Eligibility

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-b

Eligibility text quoted from the official Grants.gov listing.

About This Opportunity

This Notice of Funding Opportunity (NOFO) invites researchers to submit applications for support of clinical projects that address critical needs for clinical trial readiness in rare diseases. The initiative seeks applications that are intended to facilitate rare diseases research by enabling efficient and effective movement of candidate therapeutics or diagnostics toward clinical trials, and to increase their likelihood of success. This could be through the development and testing of rigorous b …

Description from the official Grants.gov listing — read the complete notice, including any updates, on Grants.gov before applying.

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