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Open Federal Grants · National Institutes of Health

Exploratory Clinical Neuroscience Research on Substance Use Disorders (R61/R33 Clinical Trial Optional)

National Institutes of Health · Opportunity PAR-27-053 · Award amount: see the official listing

Opportunity NumberPAR-27-053
Award FloorNot stated in the listing
Award CeilingNot stated in the listing
Cost Sharing / MatchingNot required by the listing
Application DeadlineJun 16, 2028
Last Updated on Grants.govAug 31, 2026
Who Can ApplyState governments, County governments, City / township governments, Regional organizations, U.S. territories & freely associated states, Independent school districts, Federally recognized tribal governments, Public housing authorities, Native American tribal organizations, Nonprofits with 501(c)(3) status, Nonprofits without 501(c)(3) status, Private colleges / universities, For-profit organizations, Small businesses, Other applicants

Eligibility

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domesti

Eligibility text quoted from the official Grants.gov listing.

About This Opportunity

This notice of funding opportunity (NOFO) uses a R61/R33 Phased Innovation Award activity code to support clinical research applications that are exploratory and developmental in nature and focus on understanding the neurobiological mechanisms underlying substance use disorders (SUD), including fundamental circuitry and behavior relevant to substance use. For projects not requiring a phased research approach, applicants are encouraged to apply under a different funding activity code (e.g., PA-25 …

Description from the official Grants.gov listing — read the complete notice, including any updates, on Grants.gov before applying.

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