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Open Federal Grants · National Institutes of Health

Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)

National Institutes of Health · Opportunity PAR-27-081 · Award amount: see the official listing

Opportunity NumberPAR-27-081
Award FloorNot stated in the listing
Award CeilingNot stated in the listing
Cost Sharing / MatchingNot required by the listing
Application DeadlineMar 5, 2027 — 142 days left as of Oct 14, 2026
Last Updated on Grants.govMay 4, 2026
Who Can ApplyState governments, County governments, City / township governments, Regional organizations, U.S. territories & freely associated states, Independent school districts, Federally recognized tribal governments, Public housing authorities, Native American tribal organizations, Nonprofits with 501(c)(3) status, Nonprofits without 501(c)(3) status, Private colleges / universities, For-profit organizations, Small businesses, Other applicants

Eligibility

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domesti

Eligibility text quoted from the official Grants.gov listing.

About This Opportunity

The purpose of this Notice of Funding Opportunity (NOFO) is to support investigators who have the interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets. It is expected that applicants will have, in hand, the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds.Through this NOFO, NIH wishes to stimulate research in:Discovery and development of novel, small molecules for their potential u …

Description from the official Grants.gov listing — read the complete notice, including any updates, on Grants.gov before applying.

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