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Open Federal Grants · National Institutes of Health

Preclinical Proof of Concept Studies for Rare Diseases (R21 Clinical Trial Not Allowed)

National Institutes of Health · Opportunity RFA-TR-25-002 · Award amount: see the official listing

Opportunity NumberRFA-TR-25-002
Award FloorNot stated in the listing
Award CeilingNot stated in the listing
Cost Sharing / MatchingNot required by the listing
Application DeadlineJul 2, 2027 — 261 days left as of Oct 14, 2026
Last Updated on Grants.govJun 5, 2026
Who Can ApplyState governments, County governments, City / township governments, Regional organizations, U.S. territories & freely associated states, Independent school districts, Federally recognized tribal governments, Public housing authorities, Native American tribal organizations, Nonprofits with 501(c)(3) status, Nonprofits without 501(c)(3) status, Private colleges / universities, For-profit organizations, Small businesses, Other applicants

Eligibility

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-b

Eligibility text quoted from the official Grants.gov listing.

About This Opportunity

This notice of funding opportunity (NOFO) provides funding to conduct efficacy studies in an established rare disease preclinical model to demonstrate that a proposed therapeutic agent warrants further development. In addition to preclinical efficacy, accompanying pharmacodynamic and pharmacokinetic studies would be supported. Therapeutic agents include small molecules, biologics or biotechnology-derived products. The goal of this NOFO is to spur therapeutic development for a variety of rare dis …

Description from the official Grants.gov listing — read the complete notice, including any updates, on Grants.gov before applying.

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